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Synopsis The emergence and spread of infectious diseases is a significant contributor to global amphibian declines, requiring increased surveillance and research. We assessed host–vector–parasite dynamics using a population of eastern hellbender salamanders (Cryptobranchus alleganiensis) that harbor leeches (Placobdella appalachiensis) that transmit endoparasitic blood parasites (Trypanosoma spp) to the host, with coinfection frequently occurring. We centered our study on adult males throughout their extended 8-month paternal care period because recent research indicates that nest failure caused by lack of paternal care and filial cannibalism is contributing to hellbender population declines. Recognizing the potential for parasites to modulate host physiology and behavior, we explored how infection severity influences paternal health and reproductive success. We assessed white blood cell profiles of adult male hellbenders in response to parasites, coinfection, and seasonal temperature fluctuations, while also investigating whether parasite infection or coinfection was predictive of nest success. We found that hellbenders exhibited seasonal shifts in white blood cell indices; as temperatures increased across seasons (from 5°C to 20°C), the proportion of neutrophils and eosinophils decreased (by 14% and 46%, respectively) in circulation while the proportion of lymphocytes and basophils increased (by 8% and 101%, respectively). Moreover, the proportion of neutrophil precursors increased by 80% under colder temperatures, which signifies seasonal immune cell recruitment. We demonstrated that neutrophils and eosinophils increased while lymphocytes decreased in response to leech infection. However, as leech and trypanosome infection intensity increased together, the proportion of lymphocytes increased while neutrophils and eosinophils decreased, underscoring the complex interactions between coinfection and immune responses of hellbenders that warrant future research. Despite the influence of infection and coinfection on hellbender physiology, we detected no evidence to support the hypothesis that parasites influence the likelihood of nest failure or whole-clutch filial cannibalism. In light of amphibian declines being exacerbated by climate change and disease, our study emphasizes the need to establish hematological reference values that account for physiological adaptations to seasonal fluctuations in temperature and different life history stages and to study the physiological responses of imperiled amphibian species to parasites. 

ABSTRACT Understanding quenching mechanisms in low-mass galaxies is essential for understanding galaxy evolution overall. In particular, isolated galaxies are important tools to help disentangle the complex internal and external processes that impact star formation. Comparisons between quenched field and satellite galaxies in the low-mass regime offer a substantial opportunity for discovery, although very few quenched galaxies with masses below $$M_{\star }\, \sim \, 10^{9} {\rm M}_{\odot }$$ are known outside the virial radius, Rvir, of any host halo. Importantly, simulations and observations suggest that an in-between population of backsplash galaxies also exists that may complement interpretations of environmental quenching. Backsplash galaxies – like field galaxies – reside outside the virial radius of a host halo, but their star formation can be deeply impacted by previous interactions with more massive systems. In this paper, we report the concurrent discovery of a low-mass ($$M_{\star }\, \sim \, 10^{7} {\rm M}_{\odot }$$) quenched galaxy approximately 1Rvir in projection from the M81 group. We use surface brightness fluctuations (SBF) to investigate the possibility that the new galaxy, dw0910+7326 (nicknamed Blobby), is a backsplash galaxy or a more distant field galaxy. The measured SBF distance of $$3.21\substack{+0.15 +0.41 \\-0.15 -0.36}$$ Mpc indicates that Blobby likely lies in the range 1.0 < R/Rvir < 2.7 outside the combined M81–M82 system. Given its distance and quiescence, Blobby is a good candidate for a backsplash galaxy and could provide hints about the formation and evolution of these interesting objects. 

Abstract The²⁰Ne(α,p)²³Na reaction rate is important in determining the final abundances of various nuclei produced in type Ia supernovae. Previously, the ground state cross section was calculated from time reversal reaction experiments using detailed balance. The reaction rates extracted from these studies do not consider contributions from the population of excited states, and therefore, are only estimates. A resonance scan, populating both the ground and first excited states, was performed for the²⁰Ne(α,p)²³Na reaction, measuring between 2.9 and 5 MeV center of mass energies at the Nuclear Science Lab at the University of Notre Dame. Data analysis is underway and preliminary results show substantial contribution from the excited state reaction. 

Abstract As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate aging mechanisms and precipitate the development of therapeutic interventions to support healthy aging. The Fifth Annual Midwest Aging Consortium Aging Research symposium, held from April 28 to 30, 2024, was hosted by The Ohio State University in Columbus, Ohio, and featured presentations from investigators across the Midwestern United States. This report summarizes the research presented at the symposium, whose topics included cellular senescence and the aging brain, metabolism and metabolic interventions, nutrition, redox mechanisms and biomarkers, and stress mechanisms. Abstract presentations and short talks highlighted early-stage and young investigators, whereas 2 keynote presentations anchored the symposium. Overall, this symposium showed the robustness of aging research in the Midwest and underscored the advantages of a collaborative approach to geroscience research. 

Abstract The Midwest Aging Consortium (MAC) has emerged as a critical collaborative initiative aimed at advancing our understanding of aging and developing strategies to combat the rising prevalence of age-related diseases. Founded in 2019, MAC brings together researchers from various disciplines and institutions across the Midwestern United States to foster interdisciplinary geroscience research. This report summarizes the highlights of the Fourth Annual Symposium of MAC, which was held at Iowa State University in May 2023. The symposium featured presentations on a wide array of topics, including studies on slow-aging animals, cellular senescence and senotherapeutics, the role of the immune system in aging, metabolic changes in aging, neuronal health in aging, and biomarkers for measuring the aging process. Speakers shared findings from studies involving a variety of animals, ranging from commonly used species such as mice, rats, worms, yeast, and fruit flies, to less-common ones like naked mole-rats, painted turtles, and rotifers. MAC continues to emphasize the importance of supporting emerging researchers and fostering a collaborative environment, positioning itself as a leader in aging research. This symposium not only showcased the current state of aging biology research but also highlighted the consortium’s role in training the next generation of scientists dedicated to improving the healthspan and well-being of the aging population. 

ABSTRACT We present the first satellite system of the Large Binocular Telescope Satellites Of Nearby Galaxies Survey (LBT-SONG), a survey to characterize the close satellite populations of Large Magellanic Cloud to Milky-Way-mass, star-forming galaxies in the Local Volume. In this paper, we describe our unresolved diffuse satellite finding and completeness measurement methodology and apply this framework to NGC 628, an isolated galaxy with ∼1/4 the stellar mass of the Milky Way. We present two new dwarf satellite galaxy candidates: NGC 628 dwA, and dwB with MV = −12.2 and −7.7, respectively. NGC 628 dwA is a classical dwarf while NGC 628 dwB is a low-luminosity galaxy that appears to have been quenched after reionization. Completeness corrections indicate that the presence of these two satellites is consistent with CDM predictions. The satellite colours indicate that the galaxies are neither actively star forming nor do they have the purely ancient stellar populations characteristic of ultrafaint dwarfs. Instead, and consistent with our previous work on the NGC 4214 system, they show signs of recent quenching, further indicating that environmental quenching can play a role in modifying satellite populations even for hosts smaller than the Milky Way. 

Abstract We present observations of ≳10–100 keV nucleon −1 suprathermal (ST) H, He, O, and Fe ions associated with crossings of the heliospheric current sheet (HCS) at radial distances of <0.1 au from the Sun. Our key findings are as follows: (1) very few heavy ions are detected during the first full crossing, the heavy-ion intensities are reduced during the second partial crossing and peak just after the second crossing; (2) ion arrival times exhibit no velocity dispersion; (3) He pitch-angle distributions track the magnetic field polarity reversal and show up to ∼10:1 anti-sunward, field-aligned flows and beams closer to the HCS that become nearly isotropic farther from the HCS; (4) the He spectrum steepens either side of the HCS, and the He, O, and Fe spectra exhibit power laws of the form ∼ E −4 – E 6 ; and (5) maximum energies E X increase with the ion’s charge-to-mass ( Q / M ) ratio as E X / E H ∝ ( Q X / M X ) δ , where δ ∼ 0.65–0.76, assuming that the average Q states are similar to those measured in gradual and impulsive solar energetic particle events at 1 au. The absence of velocity dispersion in combination with strong field-aligned anisotropies closer to the HCS appears to rule out solar flares and near-Sun coronal-mass-ejection-driven shocks. These new observations present challenges not only for mechanisms that employ direct parallel electric fields and organize maximum energies according to E / Q but also for local diffusive and magnetic-reconnection-driven acceleration models. Reevaluation of our current understanding of the production and transport of energetic ions is necessary to understand this near-solar, current-sheet-associated population of ST ions.